Sertraline in symptomatic chronic breathlessness: a double blind, randomised trial

It’s a Thing, that we tend to publish and read studies that show that new medications or interventions improve things, rather than that a possible treatment or intervention does not help. But both are important, right? If a treatment that is being given to people is shown to not work, we need to know about that too.

The prolific team at PaCCCS including Professors Currow and Agar have published a trial of sertraline (an antidepressant) in breathlessness and found it did not improve breathlessness scores compared with those taking a placebo tablet. Quality of life improved slightly in those taking the sertraline, however. Overall, they felt that sertraline did not provide benefit.  Continue reading